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For male C57BL/6 mice temperature was kept constant at 22 2 C, and relative humidity was maintained at 50 5%

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As previously shown 26 , recombinant AT-1002, the active domain of Vibrio choleraes zonula occludens toxin (ZOT, zonulin) on average tended to decrease the transepithelial electrical resistance (TEER) in Caco-2 cell monolayers, indicating the permeability of epithelial cell monolayers (Fig

Theres a bunch of encouraging preclinical datathat is, animals and test tubesbut essentially no human studies other than a seriously unconvincing retrospective survey with no control group in Alternative Therapies in Health and Medicine

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