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Catalase (CAT) , a heme enzyme that catalyzes the decomposition of H 2 O 2 to water + molecular O 2 , provides a vital cellular antioxidant defense 570

FIGURE 1 3 Core mechanistic roles of nAChRs in nicotine addiction As pivotal members of the ligand-gated cation channel superfamily, nicotinic acetylcholine receptors (nAChRs) serve as the cornerstone of nicotine addiction neurobiology, with the complexity of their molecular architecture and functional modulation forming its fundamental basis ( 2 10 ) and 3 subunits ( 2 4 ) have been identified

2019) or aqueous extracts, shown to have antioxidant, cytoprotective, and antibacterial effects (Upadhyay et al

(2017) review systematically elaborated on the regulatory mechanisms of the microbiome on stress responses and the HPA axis