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After its synthesis, GSH is transported to the intracellular compartments, mitochondria, endoplasmic reticulum and nucleus, but most of it is released through transporters toward the extracellular space

Cells under chronic ferroptotic stress exhibited increased sensitivity not only to the ferroptosis inducer RSL-3 but also to hydrogen peroxide

Contraindications and precautions: Use caution in patients with a history of asthma, sulfite sensitivity, or known allergy to glutathione or any formulation components

Up to now, thanks to the expeditious and remarkable evolution of relevant fundamental research, many types of RCDs and their underlying mechanisms have been elucidated, consisting of apoptosis, necroptosis, pyroptosis, parthanatos, entotic cell death (entosis), netotic cell death (netosis), lysosome-dependent cell death (LDCD), autophagy-dependent cell death (ADCD), alkaliptosis, oxeiptosis, cuproptosis, and particularly ferroptosis [11,12,13]

Exclusion criteria included malignancy, cirrhosis, hepatic insufficiency, renal failure, pregnancy, or viral coinfections