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[99] From these data, SOD1 mutants are typically segregated into two broad groups: metalbinding region (MBR) mutants which exhibit impaired metal binding and diminished catalytic rates, and wildtypelike (WTL) mutants which possess more similar metalbinding affinities, structural conformations and enzymatic activities to wildtype SOD1 protein (Table 2

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doi:10.1016/j.otohns.2008.11.021 Yen TL, Driscoll CL, Lalwani AK