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However, substitutions can also occur at positions 5, 7, 3, 4, and 5

Recently, Okuda and colleagues demonstrated that intra-striatal injection of mouse syn pre-formed fibrils (PFF) in BAC- SNCA A53T/ induces a more severe syn pathology than in mice expressing wild-type human syn, as well as more severe than the intra-striatal injection of human syn PFF