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It has been reported that the serum L-Cn levels were stepwise altered in HBV-cirrhosis and HCC, and plasma L-Cn levels remain lower in patients with HBsAg loss after Peg-IFN based treatment (12, 23), suggesting L-Cn plays a critical role in affecting the outcome of chronic HBV infection

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Pregnant women and those who experience any of the following conditions should consult with a doctor to discuss risks before attempting to self-administer an enema (6-8): Chronic constipation or diarrhea A compromised immune system Kidney conditions Chemotherapy Certain GI conditions, including ulcerative colitis and Crohn's Disease Rectal prolapse Severe fecal impaction, bowel obstruction, or history of bowel obstruction Extreme abdominal pain Recent abdominal, rectal, bowel obstruction, or colon surgery (including colon removal) History of colon or colorectal cancer Electrolyte imbalances How to Administer a Coffee Enema If a doctor determines that a coffee enema might benefit you, it is helpful to understand how the enema is administered