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The roles of reactive oxygen species and antioxidants in cryopreservation

L-ascorbic acid stands out from other forms of vitamin C because its considered active

[0008] In another embodiment, the compositions comprise a skin- lightening agent selected from the group of hydroquinone, monobenzyl ether of hydroquinone, azelaic acid, kojic acid, mequinol, retinoids (e.g., tretinoin, adapalene), soy proteins, alpha-hydroxy acids (e.g., glycolic acid), trichloroacetic acid, salicylic acid, hydroquinone-beta-D-glucopyranoside, paper mulberry, glabridin, 4-isopropylcetchol, aleosin, N-acetyl-4-S-cycteaminylphenol, N-propionyl-4-S- cysteaminylphenol, N-acetyl glucosamine, tranexaminc acid, licorice extract (e.g., Glycyrrhiza Glabra (licorice) root extract), an alpha MSH antagonist (e.g., undecylenoyl phenylalanine), phytic acid or combinations thereof

GSH binds to toxins, transforming them into water-soluble compounds that can be easily excreted from the body

The first step, catalyzed by glutamate-cysteine ligase (GCL), is rate-limiting and regulated by GSH (competitive inhibitor) and by cysteine availability (Lu, 2013)