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The elucidation of the role of diseases in barrier integrity and the underlying regulatory mechanisms have improved our understanding of the intestinal barrier to allow the development of novel and potent therapeutic approaches

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While B12 deficiency is rare, some individuals may suffer from chronic health issues or autoimmune conditions, which prevents the body from properly storing or absorbing vitamin B12

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Total body water can be subdivided into two major compartments, the intracellular fluid which is fluid inside cells, and extracellular fluid which is fluid outside of cells