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Vitamin B12 (cobalamin) refers to a group of chemically-related cobalt containing molecules involved in cell processes such as DNA synthesis, fatty acid synthesis, energy production and regulation

At the enzymatic level, histone lactylation is primarily mediated by the p300/CREB-binding protein family, which utilises lactyl-CoA to catalyse lactylation of histone H3 at lysine 18 (H3K18la) [12, 14]

The valorization of this mushroom waste also provides an opportunity for secondary industries looking to develop antioxidant-based products such as nutraceuticals

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Moreover, an extensive search was conducted using different databases, including Scopus, PubMed, Google Scholar, the Cochrane Database of Systematic Reviews, and Evidence-Based Medicine reviews from the International Parkinson and Movement Disorder Society