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DHFR is a key enzyme in the process of thymidylate synthesis, catalyzing the folate reduction to THF in two steps: during the first step, folates are reduced to dihydrofolate (DHF), which are further reduced to THF (Neradil et al

After incubation, 3Ci of [methyl- 3 H] thymidine (Moravek Biochemicals

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Sneddon AA, Wu HC, Farquharson A, Grant I, Arthur JR, Rotondo D, Choe SN, Wahle KW

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