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269 Additionally, SIRT6 can modulate TNF production by regulating the TNF mRNA translational efficiency

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126 It is generally thought that the disease initiation involves activation of endothelial cells to express chemotactic factors and cell adhesion molecules that mediate recruitment of blood monocytes into the arterial intima, where they differentiate into macrophages and, following uptake of LDL particles, eventually become lipid-laden foam cells involved in atherosclerotic plaque formation

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In conclusion, despite some limitations, our pilot study provides evidence that fibrosis induced by autologous DFb injection into degenerative IVDs can conserve IVD height, which in turn maintains the mechanical properties of the IVD