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Research has shown that in HGSOC with a deficiency of tumor-infiltrating lymphocytes, EZH2 expression in cisplatin-resistant tumors is nearly twice that of normal tumors ( The high intratumoral heterogeneity (ITH) in HGSOC results in diverse molecular characteristics at different stages, consequently affecting its sensitivity and resistance to chemotherapy ( The composition and structure of the tumor microenvironment directly influence drug delivery efficiency

Whats more, many of these hard-to-treat patients, like Makris, turn out to have co-infections transmitted by the same black-legged ticks that gave them Lyme infections that dont always respond to treatments for Lyme disease itself

In human polymorphonuclear cells, Unno et al

Severe acute respiratory syndrome coronavirus 2 can sequester mitochondria and replicate within them aging those vital organelles weakening immunity