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190 As detailed earlier in this review, the recommendation that calcium supplementation could potentially prevent metformin-induced deficiency of vitamin B 12 is premature due to the existing paucity of studies

When this occurs, they may need supplements or B12 shots

As detailed in a 2025 review, they create moisture barriers, preserve hydration, regulate pH, control inflammation, and enhance skin functions

You could argue that it was just chance or maybe placebo, but equally it could have been nocebo and I could have felt worse as a result of using one that was suspect