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In vitro experiments demonstrated that agrin treatment significantly downregulated PDGFR and claudin-5 expression in a blood-brain barrier co-culture model comprising human brain microvascular endothelial cells and pericytes, suggesting that agrin may induce pericyte death and impair the integrity of the blood-brain barrier

The individual ingredients have varying levels of clinical research behind them, but the specific combination has not undergone FDA review for safety, effectiveness, or quality

Low cerebral energy metabolism in hepatic encephalopathy reflects low neuronal energy demand

Further reading [edit] An introduction to enzyme and coenzyme chemistry

Archived from the original on September 1, 2017