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Foundational research on urate evidenced that it protected erythrocytes from the ROS generated by heme oxygenase and was neuroprotective with respect to cortical and striatal neurons subjected to ischemia following middle cerebral artery occlusion in rats [77,78]

Table 3 Summary of authors practical consideration regarding the management of high-risk AML

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However, due to the potential for these medications to induce cognitive decline, especially in elderly patients, their usage has become less common in recent years

Decreasing GSH by 10-40% can completely inhibit T-cell activation in vitro