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4.3 Reproduction To ensure a required gene expression pattern to support embryonic development, the maternal (oocyte) and paternal (sperm) epigenome are remodeled to reach totipotency, driving cellular differentiation toward all cell types (Ross and Sampaio, 2018), including embryonic and extraembryonic ( i.e ., placenta) cell types

For the purposes of this review paper, we have chosen to examine the effect of glutathione on skin pigmentation and the best routes to administer it, in order to achieve high enough blood levels to be of therapeutic benefit

Therefore, the potential for endocrine disruption by phytoestrogens needs to be considered

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If you are concerned about repeated pigmentation, it is advisable to consult a dermatologist