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Variability in how individuals handle drugsdue to genetics, disease states like renal or hepatic insufficiency, age, or drug interactionscan lead to significant differences in plasma concentrations from a given dose, resulting in either therapeutic failure or adverse events

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Under such conditions, glutamine becomes deficient and is considered conditionally essential [3,5,19]

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While not approved for therapeutic or diagnostic use, its molecular behavior makes it a valuable tool for investigating fundamental biological processes