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doi: 10.1182/blood-2013-04-495515 109 LiGLiuLYinZYeZShenN

Increased lactate levels further induce H4K8la modification, forming a positive feedback loop that activates UCHL1 and glycolytic-related genes [e.g., LDHA, pyruvate kinase M2 (PKM), MYC and Yes-associated protein 1], amplifying the inhibition of ferroptosis (68)