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Description

JAK pathway targeting presents therapeutic potential for addressing SASP-mediated inflammation and frailty in aging populations (422), driving research into SASP-modulating therapeutic approaches including senolytic and senomorphic compounds (423)

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Replacement of the conserved asparagine by alanine resulted in constitutive p300 interaction and strong transcriptional activity

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Vegetarians and individuals over 50 face particularly elevated risk, as do people with digestive conditions affecting nutrient absorption

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