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Folic acid is synthetic, does not exist in nature, and must be converted through DHFRan enzyme that is extremely slow and variable in humansbefore your body can use it. It accumulates in blood as unmetabolized folic acid (UMFA), blocks folate receptors, and competes with active forms

Coleman ML, et al

2010;10(31) doi: 10.1186/1472-6882-10-31

2021;33:17011715.e1705

Role of proline and antioxidants to supplement enzymatic ROS detoxification Proline content of both the varieties was significantly increased under MDS and SDS conditions, whereas the increment was greater in the sensitive variety VA15 compared to tolerant variety VA13