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At this point, the reduced -SMA levels indicate that the bladder has transitioned from the compensatory phase to the decompensatory phase (Metcalfe et al., 2010

Table 1: Recommended Dosage Modifications for Adverse Reactions* *National Cancer Institute Common Toxicity Criteria for Adverse Events version 2 (NCI CTCAE v2)

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Cells respond to a lower ATP level with upregulation of AMP-activated kinase(s) which promote cell-protective activities which overlap with those induced by Nrf2 or sirtuins, including the support of mitochondrial function and growth as well as regulating anti-oxidative, anti-inflammatory, and cell repair functions (DNA repair, autophagy), in part via the forkhead box protein O (FOXO) 3 transcription factor pathway [43, 48, 49]

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