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The ChaC1 active site: defining the residues and determining the role of ChaC1-exclusive residues in the structural and functional stability

Quercetin inhibits SARS-CoV 3CL protease by binding to its Gln189 site, which is expressed similarly by SARS-CoV-2 and therefore provides a direct mechanistic rationale for its clinical use in acute COVID-19 (162), and also in LC patients (115) in addition to its immunoprotective, anti-inflammatory, and antioxidant actions

Zinc is best taken with food to avoid nausea, and its worth noting that zinc and copper compete for absorption long-term high-dose zinc supplementation should ideally be balanced with a small amount of copper (2mg) to prevent deficiency

New York: The McGraw-Hill Companies Inc., 2001:29913062