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It also increases collagen III for tissue flexibility and drives collagen IV production up by a remarkable 25.4-fold when combined with hyaluronic acid

108 This scenario could have serious clinical implications for organ transplant recipients who coincidentally have NF1, as these patients would have a drastically increased likelihood of developing malignant tumours on treatment with immunosuppressive drugs to prevent transplant rejection

Elliott MR, Chekeni FB, Trampont PC, Lazarowski ER, Kadl A, Walk SF, et al

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Therefore, CB-839 has been demonstrated to enhance PL-induced iron death synergistically