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The genomic regions of some of these 64 bb-CpGs are placed close to or inside genes previously associated with the respective condition

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B cells The overall number of B cells remains relatively stable throughout most of human lifespan, with a decline only observed in advanced old age, long after the initial signs of immune system inefficacy become apparent [345, 346]

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Although this preliminary finding is promising, the vaccine concept should be explored in a more suitable model like in mice that are transgenic for both human FcRn and human IgG 25,57