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However, IKK deficient mice die on 14 th day of gestation because of massive apoptosis of hepatocytes, therefore, these clinical trials have to be terminated [38, 121]

doi: 10.3164/jcbn.15-146 37 LaaksoMKuusistoJ

HIF-1 is a transcription factor that is stabilized under low oxygen (hypoxic) conditions and whose activity leads to the transcription of several metabolism genes such as hexokinase and glucose transporter-1 (Semenza, 2011)