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Briefly, mice received a single, blinded intraperitoneal injection of either vehicle control (2% DMSO in 0.9% NaCl) or dexamethasone (200 g/kg in 0.9% NaCl) in a final volume of 200 l ice-cold solution, administered 30 min prior to surgery

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PRMT5 is highly expressed in breast cancer and chronic myeloid leukemia (CML) stem cells, and the knockdown of PRMT5 or the use of PRMT5 inhibitors can significantly impair the self-renewal capacity of CSCs