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Consistent with our findings, pharmacological inhibition of MAT2A with FIDAS-5 has been reported to reduce MAT2A expression, suppress glycolytic metabolism, and impair tumor growth both in vitro and in vivo in multiple myeloma and osteosarcoma models 17,18

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In porcine coronary artery SMCs, GPR30 activation triggers RhoA/ROCK inactivation by stimulating Epac/Rap1 and protein kinase A (PKA), leading to coronary artery relaxation [85]