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Endoplasmic reticulum stress and the unfolded protein response are driven by coronavirus replication in infected cells [70,71,72,73]

Int J Mol Sci 19(10) Pecorelli A, Natrella F, Belmonte G et al (2015) NADPH oxidase activation and 4-hydroxy-2-nonenal/aquaporin-4 adducts as possible new players in oxidative neuronal damage presents in drug-resistant epilepsy [J]

These lesions frequently exhibit iron overload, oxidative stress, and inflammation, all of which can induce and exacerbate ferroptosis, thereby inhibiting the growth of lesion cells (10)