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Accumulated evidence has shown that contribution of LECs to the establishment and maintenance of an immunosuppressive TME mainly relies on T cell tolerance induction, which is mediated by four major mechanisms (105): suppression of DC-mediated T cell activation

10.1105/tpc.112.105049 62 Jourd'heuilD.Jourd'heuilF

Importantly, the process does not involve the CYP450 enzyme system, showing no inhibitory or inductive effect on clinically significant isoforms such as CYP1A2, CYP2C9, CYP2C19, CYP2D6, CYP2E1, or CYP3A4

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AI technologies are widely applied in diverse data modalities and clinical scenarios, including -blocker efficacy analysis, multi-omics data integration, medical text mining, early warning system development, wearable device data monitoring, vascular aging prediction, automated imaging analysis and interpretation, and the enhancement of nursing efficiency (8991)