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Currently approved treatments include hydroxychloroquine, some immunosuppressive medications, and some biologics

(2018) 97:e12070

However, in the inflammatory state, glucocorticoid concentrations suppress the immune response mainly by inhibiting the transmission of PRR, Fc receptors, and cytokine signaling, thereby shortening the duration of the immune response (92, 93)

In Australia, SL buprenorphine has been approved for the treatment of moderate-to-severe OUD at doses up to 32 mg daily, which delivers a buprenorphine C max of 15.6 ng/mL [26]