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Although still considered most typically after failure of traditional oral agents such as MTX, MMF, azathioprine, and acitretin due to their novelty and limited comparative data, novel targeted biologics are increasingly adopted as second-line options in clinical practice with promising efficacy and safety profiles

Unused syringes are permitted when they accompany injectable medication

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Makkar and Zhang [15, 16] reported that epidural steroid injections provided significant pain relief and reduced disability in lumbar spine

It has been the subject of over 100 peer-reviewed publications investigating its cytoprotective, angiogenic, and growth factormodulating properties in in vitro and animal model research