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IGFBP-2 actions are linked to insulin, although only in cases of hyperinsulinemia [173] where it seems to play a role on adipocyte autocrine control [174]

and (2) builds a framework for the evolution of the GST family in the cestodes to explain the sequence and functional diversity of this gene family

Taken together, these studies paint a complex picture of the role of Skp2 in cell cycle progression but suggest an important role in proliferation and likely in the pathogenesis of cancer