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A critical unresolved question is how specific innate immune triggers disrupt tolerance to melanocyte antigens presented by MHC class I molecules

This is the first clinical study using transcranial MRI-guided FUS for site-specific BBB opening in patients with brain tumours intravenously infused with doxorubicin or temozolomide

Dabrowska S, et al

The primary study outcome was the clearance of methotrexate after glucarpidase administration, which was defined as a methotrexate level of 0.05 mol/L 24 hours after the administration of methotrexate