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A 17yearold female developed encephalopathy and elevated serum ammonia levels 2 weeks after the addition of VPA to her therapy with topiramate and led to an increase in serum ammonia concentrations from 94 to 252 mol/L

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We noticed all of n 6 ( 6) PUFA and n 3 ( 3) are correlated with SLC25A11 expression or regulation cell models

From the translation of preclinical evaluation to clinical trial, model animals for IS are relatively simple and cannot fully represent the more complex pathological features of human beings

Terzopoulou, S