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Despite their advantages, peptides face ongoing limitations including stability challenges, delivery constraints, and higher costs compared to traditional pharmaceuticals

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City leaders had to either raise taxes or increase service fees sufficiently to pay the $1.3 million interest payments over the life of the bonds, and that proved difficult during the period of economic stagnation.[244] Phoenix in general fared pretty well during the Depression, but city leaders needed an expanding economy and tax base to pay off the bonds

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