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Clinical improvement was also observed in oxidative stress markers, with improvements in methionine levels (p=0.05), homocysteine levels (SAH, p=0.007) and the ratio of S-adenosylmethionine (SAMe) to SAH (p=0.007), indicating improvement with methylation at the cellular level and a decrease in oxidative stress in the body 2

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doi: 10.1016/j.nbd.2009.12.020 Summary Keywords autism spectrum disorder, excitatory-inhibitory balance, oxidative stress, EAAT2, KCC2, NKCC1, vitamin D3, GABRA5 Citation Alabdali AN, Ben Bacha A, Alonazi M, Abuaish S, Almotairi A, Al-Ayadhi L and El-Ansary AK (2025) Impact of GABA and nutritional supplements on neurochemical biomarkers in autism: a PPA rodent model study