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[19] Augmentation [edit] If therapy with antidepressants (such as selective serotonin reuptake inhibitors [SSRIs]) does not fully treat and discontinue [38] the symptoms of major depressive disorder (MDD) (also known as refractory depression or treatment resistant depression [TRD]) [39] then a second augmentation agent is sometimes added to the therapy

10.1016/j.bbrc.2016.10.086 Biochem Biophys Res Commun

303 Additionally, inhibition of mitochondrial respiration failed to rescue the ES/Cu toxicity, 303 and intracellular copper can be released from the ES/Cu complex and become bioavailable outside the mitochondria, suggesting a great likelihood of mitochondrial-independent cuproptosis

10.1016/j.nano.2017.01.014 111 WangZ.LiuY.XiaoY.XieY.WangR.ZhangY.et al (2022)

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