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An initial study with a limited sample size (39 HAPE patients and 43 controls) revealed no role of CYBA in HAPE pathogenesis in Caucasians, 119 but a larger Indian cohort (150 HAPE patients and 180 controls) linked CYBA (rs4673 and rs9932581) and GSTP1 (rs1695 and rs1138272) to elevated circulating 8-iso-prostaglandin F2 in HAPE, potentially contributing to HAPE susceptibility

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Centers for Disease Control and Prevention: About Shingles (Herpes Zoster) Mayo Clinic: Shingles treatment: Does alcohol use affect therapy? MedlinePlus: Shingles - aftercare Centers for Disease Control and Prevention: Shingles Symptoms and Complications Academy of Nutrition and Dietetics: How to Keep Your Immune System Healthy Chemotherapy: "Relation of Arginine-lysine Antagonism to Herpes Simplex Growth in Tissue Culture" Frontiers in Microbiology: "Identification of Amino Acids Essential for Viral Replication in the HCMV Helicase-Primase Complex" Frontiers in Microbiology: Identification of Amino Acids Essential for Viral Replication in the HCMV Helicase-Primase Complex Cleveland Clinic: L-Arginine Mayo Clinic: "L-Arginine" StatPearls: Biochemistry, Essential Amino Acids Integrative Medicine: Lysine for Herpes Simplex Prophylaxis: A Review of the Evidence British Journal of Clinical Pharmacology: L-lysine: Its antagonism with L-arginine in controlling viral infection

1.2 Chronic lung disease NTHi is the leading bacterial cause of infectious exacerbations in adults with chronic obstructive pulmonary disease (COPD) and the second leading cause of infections in paediatric cystic fibrosis (Marshall et al., 2022)

The quantity was determined and stored at 4 C