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Moreover, cyclosporin has been found to disrupt the pregnane X receptor (PXR) pathway, which regulates drug-metabolizing enzymes and transporters, leading to impaired bile acid metabolism and cholestasis (Shang et al

[DOI] [PubMed] [Google Scholar] 201.Li T.W.H., Zhang Q., Oh P., Xia M., Chen H., Bemanian S., Lastra N., Circ M., Moyer M.P., Mato J.M., et al

doi: 10.1038/s41392-021-00470-1 133 KangI.ChangM

This highlights the necessity for efficient, unambiguous, cost effective and rapid methods to assess if a line is up to the job, with respect to differentiation potential