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doi: 10.3389/fnins.2014.00447 217 WuX.ChiF.WangB.LiuS.WangF.WangJ.et al

Your health care provider needs to know if you have any of these conditions: kidney disease

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The pathogenesis of MTX-induced renal impairment is thought to be mediated by either MTX and its metabolites precipitating in the renal tubules or MTXs direct toxic impact on the renal tubules (Reference Widemann and Adamson6)

Results indicate that the prevalence of intestinal barrier dysfunction is higher in patients with hypertension than in those without hypertension [45, 85,86,87,88]