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Ebselen, one of the efficient GPx mimics, has shown promising results with regard to radioprotection against lethal doses of -radiation in the preliminary studies [57,58,59]

Nature 514 , 642645 (2014)

Abbreviations PTP1B: protein tyrosine phosphatase 1B APAP: acetaminophen JNK: c-jun (NH2) terminal kinase Nrf2: nuclear factor-erythroid 2-related factor IGFIR: insulin-like growth factor I receptor ALT: alanine amino transaminase GPx: glutathione peroxidase GR: glutathione reductase HO-1: heme oxigenase GCL-C: -glutamyl cysteine ligase catalytic subunit GCL-M: -glutamyl cysteine ligase modulatory subunit SKF: Src kinase family References Rumack BH

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[DOI] [Google Scholar] 98.Mar M., Morales A., Colell A., Garca-Ruiz C., Fernndez-Checa J.C