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Further studies are needed to elucidate the predisposition of some variants toward certain clinical manifestations, particularly neonatal hyperbilirubinemia, and how some variants increase in severity when co-inherited with other blood- or bilirubin-related genetic disorders

pyridoxine (B6) acts as a cofactor for over 100 enzymatic reactions including amino acid metabolism and neurotransmitter synthesis

Though they seldom act in isolation, they can be an excellent adjuvant therapy in managing vitiligo in toto

doi: 10.1016/j.scr.2020.102006

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