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Our results showed that the contribution of the TSS pathway on de novo cysteine synthesis and GSH generation is only detectable under cystine-restricted conditions, and such function is dimmed when cystine is supplemented at supraphysiological concentrations

A., Mattaini, K

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Model analysis Selection of parameters for estimation The methodology to select parameters for estimation involves first conducting local sensitivity analysis (LSA) to obtain a set of important parameters, and then determining from this set of parameters which are identifiable, that is for which parameters a value can be identified from the data, taking into account the model structure

When methionine flux is directed toward glutathione synthesis, the cycle aids in cellular defense against oxidative stress