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The MMRM technique borrows information from participants who are still adhering to the randomized medication to obtain a plausible estimate of what the placebo-adjusted weight loss would have looked like in the hypothetical situation in which all participants were assumed to adhere to the assigned treatment to the same degree as those who were reported to remain adherent throughout the trial

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Body Composition Studies suggest NNMT inhibition may support lean body composition by reducing fat while preserving muscle

NNMT is an enzyme that regulates energy metabolism by methylating nicotinamide, a precursor to NAD+, into 1-methylnicotinamide