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For example, experiments using carotid artery endothelial cells (CAECs) and wild-type mice with partially ligated carotid arteries showed that TMAO significantly induced NLRP3 inflammasome activation and increased caspase-1 activity, IL-1 production, and cell permeability, which contributed to the endothelial injury that initiates AS (Koka et al., 2016

Energy metabolism and cortical spreading depression susceptibility Cortical spreading depression (CSD) is a neurophysiological phenomenon characterized by the strong depolarization of regional neurons or glial cells, spreading along the cortex to neighboring regions at a rate of 35 mm/min, ultimately leading to inhibition of neural activity (9)

Such SARS-CoV-2 antigen persistence in infected tissues could possibly trigger immune perturbations that may contribute to the development of PASC

The end product of this reaction (AGE), in turn, induce oxidative stress and accelerate the Maillard reactions ultimately leading to inflammation and the propagation of tissue damage [30, 31, 32]

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