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Human umbilical vein endothelial cells (HUVECs) in culture showed significant increases in the activities of GR, GPx, GST, NQO-1, SOD, and CAT when treated with 50 M genistein (104) ( Supplementary Table 1 )

10.1080/00071660310001618334 [DOI] [PubMed] [Google Scholar] Bechtel P, Kline K

DZ (SML0305), adenine (A2786), 1 M HCl (H9892), MTA (260585), DMSO (D8418), SAM (A7007), GSK591 (SML1751) and EPZ015666 (SML1421) were purchased from Sigma-Aldrich

Moreover, NF-B pathway activation impaired the GSH/GPX4 axis by triggering HIF-2 generation (Zhang et al., 2024c)

Conclusion This review distinctively highlighted the in vitro, in vivo, and clinical studies conducted on the neuroprotective potential of natural compounds in Parkinsons disease (PD), discussing the various models of PD used, specified concentrations or doses of natural compounds, and the mechanism of their actions