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Elevated IgE levels suggest sensitization, though they may not always correlate with clinical reactivity [63]

This variability might reflect differences in study designs, populations, sample types, or covariate controls, which often included age, sex, (body mass index) BMI, smoking, alcohol consumption, sleep duration, and additional work-related factors

Banerjee et al., 2021

Similarly, another meta-analysis reported that the association between eGFR and urinary Cd was statistically insignificant, while the risk of proteinuria rose by only 35% when comparing the highest category of Cd dose metrics with the lowest Cd exposure category [16]

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