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Autoimmune Progesterone Dermatitis (APD) also known as progestogen hypersensitivity is a rare immune-mediated reaction in which the body mounts an allergic or autoimmune response to endogenous progesterone or synthetic progestins, leading to cyclical skin and systemic symptoms that worsen during the luteal phase of the menstrual cycle

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2010, titled Genetic, epigenetic, and environmental factors in serotonin-associated disease condition, estimates that genetic factors account for up to 40% of the variation in serotonin regulation, making it a significant risk factor

Ueda M, OBrien K, Rosing DR, Ling A, Kleta R, McAreavey D, Bernardini I, Gahl WA (2006) Coronary artery and other vascular calcifications in patients with cystinosis after kidney transplantation