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Recent Insights into the Structure, Regulation and Function of the V-ATPases

Deficits in B vitamins can raise homocysteine levels, which can then cause DNA damage, oxidative stress, and a persistent inflammatory state that can modify epigenetics and cause cancer (170)

4.1 AR heterogeneity and therapeutic resistance The AR, a master regulator of male reproductive physiology, exhibits profound heterogeneity across patients and tumor subclones, driven by genetic mutations (e.g., AR-V7 splice variants), post-translational modifications (phosphorylation, acetylation), and epigenetic rewiring (Zamagni et al., 2019