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developed tolcapone-loaded PLGA nanosystem to reduce the hepatotoxic effect of entacapone while retaining its therapeutic efficacy in PD as illustrated in Fig

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Many common neurological disorders list muscle twitches or spasms as symptoms, which could cause frequent and uncontrollable lip twitching

For instance, persistent activation of mTOR accelerates cellular aging, while its inhibition (e.g., by calorie restriction or rapamycin) has been shown to extend lifespan in various species (41, 42)

Jul 2015;149(1):223-237